San Diego is a capital of America\u2019s craft brew revolution, but a wine scene is also simmering in this seaside metropolis. Roughly 120 wineries call the county home, tasting rooms and wine bars are popping up from downtown to the outer \u2019burbs and restaurants serve cult bottles from far-flung regions. And don\u2019t forget the cocktails: From tiki to ice cube art, the mixology scene is equally ablaze.\r\n\r\n\r\nSips in the City\r\nMore than 400 wine bottles line the shelves at Vino Carta, a wine shop and bar in the Little Italy neighborhood, where the crowd breaks free from the Cab and Chard routine. \u201cWe struggle with\u00a0 selling Chardonnay,\u201d says Co-proprietor Patrick Ballow. \u201cPeople want more Gr\u00fcner Veltliner.\u201d In the South Park neighborhood, The Rose Wine Bar serves Hungarian Furmint and carbonic Mendocino Carignan in addition to carnitas and kabocha flatbread and gravlax toast. Carruth Cellars Wine Garden brings Sonoma to Little Italy, while Pali Wine Co. pairs Santa Barbara Pinot Noirs with salty ocean air. In North Park is N\u00e9gociant Urban Winery, which serves up big, bold reds made with grapes from around the state.\r\n\r\n\r\nBeyond Wine\r\nYou\u2019d be silly to hit San Diego and not explore the beer scene. Might as well chow down on vegan comfort food while you\u2019re at it. That\u2019s the formula at Modern Times Far West Lounge in Encinitas, where you can rinse down kimchi mayo corn and green papaya salad with hazy IPAs.\r\n\r\nFalse Idol, a speakeasy through a walk-in cooler in Craft & Commerce restaurant, revives the city\u2019s golden era of tiki drinks. Closer to La Jolla is Raised By Wolves, another speakeasy that\u2019s behind a bookcase, where The Addams Family-evoking decor showcases a deep menu of boozy classics.\r\n\r\n\r\nRestaurant Lists to Love\r\nThe Fishery is the restaurant arm of a 41-year-old wholesale seafood company, so the food\u2019s always fresh. Today\u2019s wine list is equally zesty: Burgundy and Beaujolais, of course, but now Corsican Sciacarello, ros\u00e9 of Sicilian Nerello Mascalese and a small selection from Switzerland.\r\n\r\nMexico\u2019s Valle de Guadalupe wine region is a couple of hours away, and Puesto at the Headquarters offers bottles and pours from there. Try a flight or a bottle of Chenin Blanc by Bodegas Henri Lurton alongside ceviche verde and pomegranate-flecked guacamole.\r\n\r\nAt Cucina Urbana, a bottle shop-meets-trattoria with five outposts, you\u2019ll find chicken liver p\u00e2t\u00e9 with Barolo-soaked figs, lemon ricotta-stuffed squash blossoms and guanciale-laced bucatini. Choose a well-priced bottle from the shop to accompany.\r\n\r\n\r\nEscondido\u2019s Enological Entrepreneurs\r\nAbout 40 minutes from downtown San Diego, Escondido is the county\u2019s winemaking hub. Make a reservation to visit J. Brix Wines, where Emily Towe and Jody Brix Towe make San Diego and Central Coast bottles like Riesling p\u00e9t-nat, skin-contact Pinot Gris and Stay in Bed Red. In the same facility is Vesper Vineyards, where Chris Broomell and Alysha Stehly produce Carignan, Picardan and a Marsanne-Cinsault blend.\r\n\r\nHungry Hawk Vineyards & Winery offers a more traditional estate experience, as does Orfila Vineyards and Winery, whose Italian varieties do well; try Central Coast-sourced Pinot Noir while you\u2019re there.\r\n\r\n\r\nHaute Hotels\r\nThe nightlife-peppered Gaslamp Quarter went luxe when Pendry San Diego opened. Use a gold coin for a split of Mo\u00ebt & Chandon from the vending machine, then saddle up to Provisional for a brunch like breakfast pizza or an ostrich egg omelet washed down with a mezcal-strawberry Bloody Mary.\r\n\r\nAt Rendezvous, a Francophile cocktail bar inside The U.S. Grant, a Luxury Collection Hotel, San Diego, sip the French thyme and rosemary liqueur-flavored Le Coq that\u2019s chilled with expertly carved ice. Sample the menu at the Grant Grill, where classics like Loire bubbly and Mosel Riesling accompany rich fare.\r\n\r\nWine director Chris Russo offers sage advice on wines to accompany Jason Knibb\u2019s cuisine at Nine-Ten Restaurant and Bar inside the La Jolla\u2019s Grande Colonial hotel, where the sound of the sea mixes with the buzz of village shopping.