A Bolivian winemaker describes La Paz as \u201cchaos, color and kitsch.\u201d Indeed, the city bursts with dozens of ethnic groups that intersect over food, culture and dress. It\u2019s the world\u2019s highest capital, at nearly 12,000 feet in elevation, and it\u2019s packed with dynamic restaurants, internationally recognized wineries and gripping scenery. It has all the makings for a trip of a lifetime.\r\n\r\n\r\nDrink\r\nBolivian wine is commonplace at restaurants, though selections typically cover the bigger players: Campos de Solana, Bodegas Kohlberg, Bodegas y Vi\u00f1edos La Concepci\u00f3n, Aranjuez and higher end Vinos 1750. To taste pours from tiny labels, try Hay Pan. The owner, Sukko Stach, opened this wine bar to fill a niche, along with a coffee shop based on a similar premise, Antigua Miami. Umawi Coffee & Bar, which translates to \u201clet\u2019s drink\u201d in the indigenous language of Aymara, taps the region\u2019s flora for its creative cocktail program.\r\n\r\nIt also serves Bolivian espresso drinks and quirky, minimal-intervention wines. For city views in swank surroundings, savor a glass of Tannat at +591 Bar inside the Atix Hotel, the city\u2019s sleekest property. In addition to creative burgers and custom toppings, Crafted Burgers N\u2019 Beers offers a solid roster of Bolivian craft beers.\r\n\r\n\r\nEat\r\nGustu kicked off La Paz\u2019s restaurant revolution. Established in 2013 by Noma co-founder Claus Meyer, the nightly tasting menu offers a paean to Bolivian products. Its sommelier, Bertil Levin T\u00f8ttenborg, works closely with small producers and champions natural wines. In a similar vein, vegan eatery Ali Pacha plays with texture, flavor and presentation. Sebasti\u00e1n Quiroga sources ingredients from the Amazon to the Altiplano, reconstructing everything from potatoes to corn. He also supports natural wine producers.\r\n\r\n\r\n\r\nFor handmade pastas and vegetables from Gabriela Prudencio\u2019s garden, visit Italian-leaning Propiedad P\u00fablica. Jard\u00edn de Asia prepares Andean-Amazonic food with an Asian twist alongside mainstream Bolivian brands. Popular Cocina Boliviana, opened by Sukko Stach, serves an updated version of the three-course lunch. The Atix Hotel\u2019s Ona has a strong local wine list to pair with its modern Bolivian cuisine.\r\n\r\n\r\nShop\r\nSecond only to its wines are La Paz\u2019s textiles, and you can snag traditional rugs and colorful pillow shams at bargain prices. Start a spree in Mistura, a lifestyle and concept store co-owned by a member of the Bodega Sausini family. Sausini wines are for sale alongside alpaca ponchos and scarves. For fine wares by Bolivian artisans, Walisuma stocks clothes and jewelry. Spend an afternoon in the mystical Mercado de las Brujas, or Witches\u2019 Market, which focuses on tourist trinkets. Adjacent streets are chock-full of vendors, including Fair Trade markets like Ayni Bolivia.\r\n\r\n\r\nSee\r\nTo skip the world\u2019s largest salt flat would be folly. The mesmerizing Salar de Uyuni, created by prehistoric lakes that dried into a mind-bending crystalline plain, is a great day trip. Tour operator Black Tomato arranges custom tours (pricing upon request) that include lunch paired to Bolivian wines amid the dazzling flats. It also serves sundowners that feature a selection of wines and singani, the local grape spirit. Bring your camera.\r\n\r\n\r\n4 Hour Getaway\r\nPractically kissing the Argentine border, Tarija is home to Bolivia\u2019s critical mass of vineyards and only organized wine route. Valle de Concepci\u00f3n, just beyond the city, is the main production valley. Grapes grow at around 6,200 feet, and the resulting wine is high quality. You\u2019ll find big reds like those from Salta, Argentina. Campos de Solana delivers the most sophisticated experience, with polished wine offerings. Its white, TRIvarietal, wins awards. Also visit Aranjuez, Bodegas y Vi\u00f1edos La Concepci\u00f3n and Bodegas Kohlberg. For lunch, sip robust reds with beef at El Fog\u00f3n del Gringo.